PEOPLE: CURRENT LAB MEMBERS

Hepan Tan, PhD
Postdoctoral Fellow
Department of Chemistry and Chemical Biology
Harvard University
12 Oxford St.
Cambridge, MA 02138
Tel: (617) 384-7393
Fax: (617) 384-9228
hepantan@fas.harvard.edu

Research Summary

My Ph.D. study was in the field of computer-aided drug design (CADD). In order to design HIV-1 entry inhibitors multiple technologies were applied including ligand-protein docking/virtual screening, de novo design, QSAR/pharmacophore modeling as well as molecular dynamics simulations. I also analyzed protein flexibility and rigidity with Graph Theory based approach. I am working on designing ligands with anti-cancer activity currently.

Publications

1. Tan H, Rader AJ, Identification of putative, stable binding regions through flexibility analysis of HIV-1 gp120, Proteins. 2008 Aug 14.
2. Liu J, Tan H, Rost B, Loopy proteins appear conserved in evolution, J Mol Biol. 2002 Sep 6;322(1):53-64.